Oferty pracy w projektach finansowanych przez NCN
Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.
Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.
Oferta pracy
Nazwa stanowiska: Postdoc (2 stanowiska)
Wymagania:
We are looking for a highly motivated Postdoctoral Fellow to join the homocysteine pathophysiology research group led by prof. dr hab. Hieronim Jakubowski. The Jakubowski lab looks to uncover the molecular and cellular mechanisms by which dysregulation of one-carbon and homocysteine metabolism accelerates Alzheimer’s disease. We want to learn how homocysteine and related metabolites such as homocysteine thiolactone (HTL) and homocysteine-modified protein (N-Hcy-protein) dysregulate microRNA-dependent epigenetic regulation of mTOR signaling and autophagy, processes that are important for the brain homeostasis and cognition. We use mouse and cellular models of Alzheimer’s disease and a wide array of techniques including analysis of gene expression, RNA and protein chemistry methods, proteomics, chromatin immunoprecipitation (CHIP), immunohistochemistry, confocal fluorescence microcopy, and neurophysiological testing.Applicants should have (1) a PhD degree (either completed or nearly completed), (2) experience in biochemistry, neurobiology, cell biology, or molecular biology, (3) experience in animal models and/or confocal microscopy is welcome, (4) high motivation, initiative, enthusiasm, and readiness to learn new skills, and (5) a record of publication. To apply, please email a CV, a letter summarizing research accomplishments and interests, and the contact information for three references to jakubows@rutgers.edu or jakubows2@gmail.com
Opis zadań:(1) To investigate effects of Blmh deficiency on the development of biochemical and cognitive hallmarks of Alzheimer's disease, using a Blmh-depleted 3xTg-AD mouse model fed with control or hyperhomocysteinemic diet by measuring (1a) cognitive performance and (1b) accumulation of Aβ and pTau deposits in the brain.
(2) To elucidate the mechanisms by which Blmh deficiency can accelerate the development of Alzheimer's disease, by using the Blmh-depleted 3xTg-AD mouse model fed with control or hyperhomocysteinemic diet, as well as by altering Hcy, HTL, and N-Hcy-protein levels in mouse neuroblastoma cells (N2A-APPSwe) to test: (2a) endoplasmic reticulum stress and unfolded protein response, and apoptosis; (2b) neuro-inflammation and immune response; (2c) microRNA and epigenetic regulation of mTOR signaling and autophagy.
Termin składania ofert: 20 września 2024, 23:59
Forma składania ofert: email
Warunki zatrudnienia:
• The offer is for one year with a possibility of extension for another year contingent on the progress.
• Salary 10,000 PLN/month
PULS is an equal opportunity employer and provides comprehensive health insurance.
• Access to state-of-the art facilities
More information about the lab can be found at https://kbib.up.poznan.pl
Requests for additional information should be directed to jakubows@rutgers.edu or jakubows2@gmail.com.
Applicants should include and sign the following consent clause in their applications: ‘’I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation).’’