Oferty pracy w projektach finansowanych przez NCN
Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.
Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.
Oferta pracy
Nazwa stanowiska: POST-DOCTORAL
Wymagania:
Expectations towards candidates:
1. Doctorate in the field of biology, biotechnology, molecular biology, biophysics,
biochemistry.
2. Practical and theoretical knowledge of molecular biology and biochemistry.
3. Knowledge in the field of transcriptomic data analysis will be an asset
Project description:
The mRNA 3' end polyadenosine tail is crucial for RNA stability, export and translation.
Deadenylation is a cytoplasmic process of shortening the poly(A)-tail that is a license to
subsequent transcript decapping by Dcp1/2 and degradation by Xrn1. There are two
deadenylation complexes in the cytoplasm, CCR4-NOT and PAN2/3, which harbor three
enzymes, individually quite well studied in vitro. However, the in vivo role of those enzymes
has not been yet deciphered. We will study the in vivo mechanism of deadenylation in the
budding yeast model using the Direct RNA Sequencing technique from Oxford Nanopore
Technologies, which enables to determine both RNA levels and polyA-tail lengths. We will
inquire whether and to what extent the function of the deadenylation and decay machinery is
altered by translation, during stress response or changing growth conditions. A good
experience in work with budding yeast is crucial. A knowledge of human cell line culture and
bioinformatics will be most welcomed. Depending on the workload the candidate will be free
to propose alternative projects.
Termin składania ofert: 15 września 2024, 23:59
Forma składania ofert: email
Warunki zatrudnienia:
Institute of Biochemistry and Biophysics
Polish Academy of Sciences
National Science Center SONATA GRANT
"Novel mechanism of gene expression control in Eukaryota through regulation of
protein-coding transcript polyadenosine tail length"
Keywords: molecular biology, polyadenosine tail, mRNA, RNA degradation, deadenylation,
nanopore direct RNA sequencing
Type of post: post-doc / assistant
Type of contract: fixed-term full time employment
Remuneration: ~ PLN 7,000
Employment period: 24 months with possibility of extension
Date of commencement of work: no later than 1st October 2024
Principal Investigator: Dr Agnieszka Tudek (atudek@ibb.waw.pl)
List of documents (preferably merged into one file):
1. Documentation of the doctoral degree (doctorate cannot be older than 7 years)
2. CV
3. cover letter
4. contact or letter of recommendation from the previous employer or doctorate supervisor
Evaluation of candidates will consist of:
1. In the first stage the Selection Committee, composed of Project Manager and two
independent researchers from IBB PAN) will select eligible candidates. We reserve the right
to contact selected candidates.
2. In the second stage the candidates will be interviewed by the Selection Committee. The
candidate will be asked to briefly present his or hers CV and outline one main scientific
project, which will be then discussed in more detail with the Selection Committee. During the
meeting the candidate will be free to inquire about details concerning the project.
Contact for formal and informal inquiries: atudek@ibb.waw.pl
Deadline for submitting applications: 15th September 2024
Please include the following consent to process personal data (applications not
including this statement will not be processed for legal reasons):
„Wyrażam zgodę na przetwarzanie moich danych osobowych dla potrzeb niezbędnych do realizacji
procesu rekrutacji zgodnie z Ustawą z dnia 29 sierpnia 1997 r. o ochronie danych osobowych ( Dz. U.
z 2016 r. poz. 922 z późń. zm.)”