Oferty pracy w projektach finansowanych przez NCN
Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.
Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.
Oferta pracy
Nazwa stanowiska: PhD Student in Monika Kluzek group
Wymagania:
Candidate Profile
We seek motivated individuals with:
- MSc in Physics, Biology, or related fields (completed or near completion)
- Strong interest in interdisciplinary research at the interface of physics and biology
- Experience in fluorescence microscopy, membrane biophysics and/or bacterial culture (advantageous)
- Problem-solving skills and ability to work independently
- Ability to work effectively in a team
- Fluency in spoken and written English
Key responsibilities
- Investigating the role of modified lipid and protein compositions in OMV uptake efficiency by bacterial cells using biochemical approaches.
- Conducting high-throughput and high-resolution microscopy techniques to track OMV interactions with bacterial membranes and cargo release processes.
- Developing and optimizing protocols for the encapsulation of antimicrobial agents within OMV-based carriers, including active loading methods to enhance encapsulation efficiency.
- Performing in vitro assays, including fluorescence assays, and biofilm eradication assays, to quantify OMV delivery efficiency and antimicrobial efficacy.
- Collaborating with external partners for advanced microscopy techniques (STORM, CLEM)
Termin składania ofert: 8 grudnia 2024, 00:00
Forma składania ofert: formularz rejestracyjny
Warunki zatrudnienia:
We Offer
- Full-time scholarship for 48 months (including probation period)
- Competitive salary: 5.000 PLN/month netto
- Access to state-of-the-art research facilities and in-house services
- A highly collaborative and interdisciplinary research environment
- Professional development opportunities (conferences, courses, postgraduate studies)
- Assistance with relocation and settling in Warsaw
PhD position (m/f/d): Understanding the mechanism of bacterial outer membrane vesicles (OMVs) uptake for targeted delivery
The International Institute of Molecular Mechanisms and Machines (IMol) of the Polish Academy of Sciences invites applications for a 4-year PhD position in the laboratory of Dr. Monika Kluzek.
Project Overview
Gram negative bacteria constantly communicate across one another using outer membrane vesicles (OMVs) and employ them for a plethora of pathophysiological functions within microbial communities. To modulate a response in recipient bacteria, OMVs must be taken up and their biomolecular cargo has to reach the cytosol; how such nanometric vesicles cross the two bacterial membrane layers to finally release their content is still unknown. This project involves using a multidisciplinary approach, combining fluorescence spectroscopy and confocal microscopy, cryoEM and cryoET, and microbiology methods to investigate the mechanism of OMVs uptake by gram-negative bacteria, by focusing on how OMVs membrane biophysical properties regulate the uptake/release process, and how to harness this novel insight to create OMV-based drug carriers for targeted delivery.
About IMol
The International Institute of Molecular Mechanisms and Machines (IMol) is a new research institute of the Polish Academy of Sciences dedicated to groundbreaking research in biological, chemical, and medical sciences. Located in Warsaw, IMol provides dynamic platform for interdisciplinary studies, state-of-the-art facilities supporting innovative research, a stimulating international environment, and opportunities for collaboration across scientific boundaries.
How to Apply
Please submit Cover letter detailing your motivation and relevant expertise, CV with contact information for at least two academic references and copies of academic transcripts.
Where to Apply
https://forms.gle/Exoy7iw4U8cYLL9C6
Application deadline: 8th December 2024
Offer starting date: 16th December 2024
For further information, please contact Dr. Monika Kluzek at m.kluzek@imol.institute or visit www.imol.institute
IMol is committed to equality, diversity, and inclusion in its recruitment process.