Oferty pracy w projektach finansowanych przez NCN

Nazwa jednostki: Adam Mickiewicz University – Poznań, Inne oferty z tego miasta »
Nazwa stanowiska: PostDoc in project
Wymagania:

Requirements and qualifications:
- The successful candidate must have a Ph.D. degree in biology, biochemistry, chemistry, genetics, computational biology or related life science field;
- Proven record of productivity and publications in high-impact journals;
- Required languages: Polish or English (level good or better);
- Experience in human molecular genetics, molecular and cellular biology;
- An ideal position for candidates who have already come into contact with research on mouse models, experiments related to biochemistry and RNA biology or whole transcriptome research techniques.

Opis zadań:

Project leader: Prof. Krzysztof Sobczak
Project title: Pathogenesis driven by RNAs with expansion of trinucleotide repeats: mechanisms and therapeutic strategies

Position for PostDoc available at the Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Adam Mickiewicz in Poznań, which is the largest academic center in Poznań and one of the best centers in Poland (ID-UB status).
We are looking for people interested in research work in a team dealing with research related to human molecular genetics, under the direction of Professor Krzysztof Sobczak. The team's interests focus primarily on the study of the molecular basis and the development of experimental therapy for selected neurodegenerative diseases associated with the occurrence of trinucleotide repeat expansion (myotonic dystrophies - DM, and fragile X syndromes - FXS and FXTAS).
DM1 is an autosomal dominant disorder caused by CTG repeat expansion in the 3'-UTR of the DMPK gene. The DMPK transcript contains extended CUG repeats (CUGexp) and is retained in the nucleus in the form of nucleoprotein clusters (foci). This nuclear retention of the DMPK transcript is in part a consequence of the interaction of CUGexp RNA with CUGexp binding proteins, such as splicing factors belonging to the Muscleblind-like protein (MBNL) family. The binding of hundreds of MBNL proteins to a single CUGexp RNA results in their functional deficiency and disruption of alternative splicing, a process normally regulated by these proteins.
In our research, we focus on a deeper understanding of some aspects of the molecular basis of DM and FXTAS, especially those related to RNA metabolism, the functions of individual splicing factors, and disturbances in non-canonical translation occurring directly on the sequence of trinucleotide repeats (the so-called RAN translation). We also focus on the development of therapeutic approaches using antisense oligonucleotides (ASOs) and low molecular weight compounds that prevent the interaction of CUGexp (DM) and CGGexp (FXTAS) transcripts with proteins.

Basic duties:
- Conducting experiments explaining the mechanisms of RNA recognition by MBNL proteins and the regulation of alternative splicing by these proteins - whole transcriptome approach.
- Conducting experiments explaining the mechanisms of RAN translation of CGG repeats in the 5'UTR of the FMR1 gene - whole transcriptome approach.
- Experimental therapy of DM1 and FXTAS with the use of ASO and low molecular compounds; in vitro and in animal models of these diseases.
- Participation in the preparation of publications.

Typ konkursu NCN: MAESTRO – NZ
Termin składania ofert: 20 grudnia 2024, 23:59
Forma składania ofert: email
Warunki zatrudnienia:

Fixed-term contract from 2025.02.01 to 2026.02.28, with the possibility of extension.

Monthly salary: 7 700 PLN brutto (10 000 PLN brutto-brutto)

Workplace location: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań, ul. Uniwersytetu Poznańskiego 6, 61-614 Poznań

Dodatkowe informacje:

Required documents:
- Application form/letter of the candidate;
- Professional CV including scientific achievements;
- Diplomas or certificates issued by colleges and universities attesting to education and degrees or titles held;
- Information on the Applicant’s research, teaching and organizational achievements,
- List of publications;
- Letter summarizing previous work, experience and future interests;
- Contact information for two professional references;
- Candidates will be selected through an open competition in accordance with the guidelines of the National Science Centre;

Please include the following statement in your CV: “Pursuant to Article 6 (1) of the General Regulation on the Protection of Personal Data of 27 April 2016 (Journal of Laws EU L 119/1 of 4 May 2016) I agree on the processing of personal data such as: name, (names) and surname, parents' names, date of birth, place of residence (correspondence address), education, course of previous employment, included in my job offer for the needs of current recruitment.”

The required documents should be sent to: praca-ibmib@amu.edu.pl

Application deadline: 2024.12.20, 23:59.
The competition may be extended until a suitable candidate is found who meets all the requirements.

RODO Information Clause :
Pursuant to Article 13 of the General Data Protection Regulation of 27 April 2016. (Official Journal of the EU L 119 of 04.05.2016) we inform that:
1. The controller of your personal data is Adam Mickiewicz University, Poznań with the official seat: ul. Henryka Wieniawskiego 1, 61 - 712 Poznań.
2. The personal data controller has appointed a Data Protection Officer overseeing the correctness of the processing of personal data, who can be contacted via e-mail: iod@amu.edu.pl.
3. The purpose of processing your personal data is to carry out the recruitment process for the indicated job position.
4. The legal basis for the processing of your personal data is Article 6(1)(a) of the General Data Protection Regulation of 27 April 2016 and the Labour Code of 26 June 1974. (Journal of Laws of 1998 N21, item 94 as amended).
5. Your personal data will be stored for a period of 6 months from the end of the recruitment process.
6. Your personal data will not be made available to other entities, with the exception of entities authorized by law. Access to your data will be given to persons authorized by the Controller to process them in the performance of their duties.
7. You have the right to access your data and, subject to the law, the right to rectification, erasure, restriction of processing, the right to data portability, the right to object to processing, the right to withdraw consent at any time.
8. You have the right to lodge a complaint to the supervisory authority - the Chairman of the Office for Personal Data Protection, ul.Stawki 2, 00 - 193 Warsaw.
9. Providing personal data is mandatory under the law, otherwise it is voluntary.
10. Your personal data will not be processed by automated means and will not be subject to profiling.

Data dodania ogłoszenia: 2024-11-13 10:50:48