Oferty pracy w projektach finansowanych przez NCN
Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.
Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.
Oferta pracy
Nazwa stanowiska: Postdoctoral Researcher
Wymagania:
Necessary Requirements:
• PhD degree in biological sciences, neurosciences, pharmacological sciences, medical sciences or relevant,
• experience in laboratory techniques in biochemistry, molecular biology (e.g. DNA, RNA, isolation; Western blot; qPCR; immunohistochemistry; spectrophotometric/fluorometric techniques),
• experience in planning and conducting in vivo procedures (e.g. behavioral analysis),
• working knowledge of statistical software (e.g. GraphPad Prism),
• ability to work in a team and independently,
• excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts,
• indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.
The area of the research in which the candidate would participate:
Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). This project will characterize the mechanisms by which α-syn–induced parkin dysfunction modulates mitochondrial damage and associated immune response in a pre-clinical murine model of PD based on bilateral injection of oligomeric α-syn into the striatum of C57BL/6J, parkin knock-out (Park2-/-) and parkin overexpressing (PARK2oe) mice. We are seeking a postdoctoral researcher for the project aimed to investigate parkin’s involvement in α-syn–evoked mitochondrial damage, inflammatory response, and neurodegeneration in our murine PD models. Candidate will be involved in investigation of:
1) the time-dependent impact of α-synuclein administration on inflammatory responses and parkin function;
2) the role of parkin in regulating the brain inflammatory response and neurodegeneration after intrastriatal administration of α-synuclein;
3) the effect of parkin overexpression in neuroanatomical and morphological changes evoked by α-synuclein;
4) the effects of pharmacological modulation of mitoflammation on neurodegeneration and behavioral disturbances caused by α-synuclein administration;
Addressing the role of parkin at the crossroads of α-syn spreading and neuroinflammation holds the promise for better understanding of PD pathomechanism and identification of novel therapeutic targets.
Description of duties:
• planning and implementation of research tasks in accordance with the schedule of the project,
• designing and conducting experiments with the use of biochemistry, molecular biology and microscopic imaging methods,
• analysis of obtained data,
• presenting the results at the group meetings, external seminars and scientific conferences,
• preparation of scientific publications,
• introducing new research technologies and cooperation with a foreign partner involved in the current research project.
Termin składania ofert: 15 grudnia 2024, 23:55
Forma składania ofert: email
Warunki zatrudnienia:
We offer:
• fixed term, full-time employment contract,
• contract period: January 2025 – November 2025,
• the opportunity to work in a pleased atmosphere, in a dynamic, developmental research group,
• scientific collaboration with a research partner in Germany and with other Polish and foreign research institutions,
• opportunity to participate and present obtained results at international conferences.
How to Apply:
Please send your documents to aadamczyk@imdik.pan.pl indicating the reference number ZKTS-110-1/2024 in your correspondence.