Oferty pracy w projektach finansowanych przez NCN

Nazwa jednostki: The International Institute of Molecular Mechanisms and Machines (IMol), Polish Academy of Sciences – Warsaw, Inne oferty z tego miasta »
Nazwa stanowiska: Postdoctoral researcher in Konarska group
Wymagania:

Profile of candidates/requirements:
- PhD degree in molecular biology, biophysics, biochemistry or related fields of life sciences,
- Solid knowledge and familiarity with laboratory techniques in at least one of the following disciplines: molecular biology, biochemistry, cell biology, genetics, transcriptomics,
- Very good command of English,
- Motivation and passion for experimental work.

Opis zadań:

We are looking for a highly motivated person to:
- Perform experiments using biochemical, molecular biology or genetic techniques (independently and in collaboration with other team members),
- Participate in experimental design and data analysis,
- Participate in the data preparation and writing of manuscripts,
- Actively participate in lab meetings, scientific seminars and conferences.

Typ konkursu NCN: OPUS – NZ
Termin składania ofert: 4 maja 2025, 23:59
Forma składania ofert: formularz rejestracyjny
Warunki zatrudnienia:

We offer:
- Full-time position for up to 4 years with the possibility of extension. Initial contract signed for 12 months, salary: ~6.900 PLN net/month,
- Work in a young, active team in an excellent scientific environment,
- Comprehensive training in genetics, biochemistry and molecular biology,
- Access to the state-of-the-art equipment and facilities,
- Participation in courses and conferences.

Dodatkowe informacje:

IMol is looking for a candidate for the position of Postdoctoral Researcher

Group Leader: Prof. Magda Konarska https://imol.institute/leaders/konarska-group/

Project title: “Quality control at the catalytic phase of splicing: defective introns and their effects of global splicing in the cell”

Download the description of the project: https://projekty.ncn.gov.pl/opisy/590812-en.pdf
Short description of the group and/or the project:
As a part of our long-term goal to understand the function of the spliceosome, this project will study the consequences of defects in the processing of introns with suboptimal 3’SS signals. Whereas wild type (wt) introns complete the 1st step and progress efficiently to the 2nd step, introns defective in the 2nd step accumulate 1st step products (lariat intermediates) or are discarded, preventing unsuitable substrates from generating spliced mRNA products. Analysis of the mechanistic basis underlying these events is critical for our ability to predict and modulate the fidelity of splicing, in particular, the selection of alternative 3’SS. The high complexity of splice site selection mechanisms in alternative splicing is well documented, however, what happens when suboptimal intron substrates, specifically mutant 3' splice site (3'SS) introns, reach the catalytic center of the spliceosome? What elements in the spliceosomal RNA core recognize and position them for catalysis? What are the quality control systems preventing the catalysis of incorrect substrates? Similarly, the existence of discard pathways for the release of lariat intermediates that cannot complete the 2nd step of splicing has been described, but the underlying mechanisms controlling this process are not known.

How to apply:
Please prepare the following documents (you will be asked to submit the documents merged into one PDF file while filling out the application form linked below):
- Motivation letter;
- CV;
- A list of publications and conferences attended;
- Contact details of previous supervisors for reference (please do not attach generic reference letters but contact details instead)

If you think you are the person we are looking for, please apply by filling in this form: https://forms.gle/Exoy7iw4U8cYLL9C6

Data dodania ogłoszenia: 2025-03-25 09:35:49