Oferty pracy w projektach finansowanych przez NCN
Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.
Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.
Oferta pracy
Nazwa stanowiska: post-doc
Wymagania:
1. Doctorate (thematically related to biology, biotechnology, molecular biology, biophysics, biochemistry or a related field). The doctoral degree cannot be obtained more than 7 years before the year of the competition announcement.; periods of childcare do not count. Persons before the defense of the PhD are admitted to the recruitment, but obtaining the PhD is a condition of employment.
2. Practical and theoretical knowledge of molecular biology and biochemistry.
3. Demonstrated skills in RNA biology or chromatin immunoprecipitation (ChIP) or protein purification or ciliate research will be an asset.
Transcription performed by RNA Polymerase II (Pol II) is highly regulated process that can generate either to mRNA or non-coding (ncRNA). The transcription machinery of the ciliate Paramecium tetraurelia seems to be perfect for studies of these two modes of RNA production, as mRNA synthesis takes place in the vegetative macronucleus while the entire genome of the generative micronucleus is transcribed only at defined time-point of the sexual cycle – meiosis - leading to genome-wide ncRNA production. Similar wave of non-coding transcription occurs in new macronucleus during its early development. We hypothesize that this developmentally specific burst of transcription would on the one hand require a very different epigenetic landscape, but on the other hand also a different composition of the Pol II complex. Clarification of these genetic and epigenetic factors dissecting differential Pol II activity is necessary to understand and to interpret the polymerase – chromatin interaction. We will base our studies on discovered and characterized TFIIS, Spt5 and Spt4 elongation factors involved in synthesis of long and short ncRNAs in Paramecium (Maliszewska-Olejniczak et al. 2015, PLOS Genetics; Gruchota et al. 2017, NAR; Owsian et al. 2022, NAR, Charment, Gruchota et al. 2024, NAR). In the present proposal, we will focus on their function in synthesis of coding and non-coding RNAs as well as their role in changes of chromatin landscape.
Typ konkursu NCN: OPUS – NZTermin składania ofert: 11 kwietnia 2025, 00:00
Forma składania ofert: formularz rejestracyjny
Warunki zatrudnienia:
Type of contract: fixed-term full time employment
Number of job offers: 1
Remuneration: ~ PLN 9,000 gross
Employment period: 12 months (with possible 12 months extension)
Date of commencement of work: Directly after recruitment (negotiable)
Name and surname of the project head: Dr. Jacek K. Nowak
Project title: "Elongation factors in synthesis of developmentally controlled non-coding RNA"
Contact for formal and informal inquiries: jknowak@ibb.waw.pl
Applications should be sent in English or in Polish via recruitment platform:
https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=69658b7d56ce4b2fba5ff29a1a2e3dbe