Oferty pracy w projektach finansowanych przez NCN

Nazwa jednostki: Hirszfeld Institute of Immunology and Experimental Therapy, PAS – Wrocław, Inne oferty z tego miasta »
Nazwa stanowiska: post-doc
Wymagania:

Requirements
1. A PhD degree in biological sciences, biotechnology, biochemistry or chemistry obtained in the year of employment in the project or within 12 years prior to 1 January of the year of employment in the project (mandatory requirement). This period may be extended in accordance with the provisions of Annex 2 to Resolution No. 115/2024 of the NCN Council of 14 November 2024, which also contains other formal requirements for candidates.
2. Theoretical knowledge of bacterial antigen immunochemistry.
3. Knowledge and experience in preparative (chromatography) and analytical (mass spectrometry, spectroscopy) methods. A combination of these skills with practical experience in microbiology or in vitro techniques is welcome.
4. Achievements indicating scientific activity, including authorship of an original publication in the field of the doctoral thesis.
5. Fluent spoken and written English.
In addition to the mandatory requirements, the Candidate's entire scientific achievements will be evaluated.

Required documents
1. Cover letter addressed to the project manager: Prof. Jolanta Łukasiewicz
2. Synthetic CV (CV)
3. Copy of a document confirming academic degree/title
4. Autobiographical summary containing information on research, teaching and organisational activities
5. List of publications
6. List and description of research internships
Welcome: letters of recommendation or details of persons who can provide such letters.

Opis zadań:

Job description
Conducting research work as a post-doc as part of the NCN SHENG 4 UMO-2025/56/Q/NZ6/00344 research project, entitled ‘Chemical synthesis, immunogenicity and identification of protective sugar epitopes of Pseudomonas aeruginosa antigens’.

Brief description of the project:
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious hospital-acquired infections in people with cystic fibrosis and severe burns. Although several vaccine candidates have entered clinical trials, the efficacy results of these preparations are insufficient and there is currently no approved vaccine against P. aeruginosa available. Lipopolysaccharide (LPS, O antigen) is one of the main surface antigens and virulence factors of this bacterium. When designing O antigen-based vaccines, naturally isolated or synthetic polysaccharides can be used. In both cases, the antigen is selected based on its immunogenicity, and in the latter case, based on access to developed and efficient chemical synthesis procedures.
The project is based on Polish-Chinese cooperation. The Chinese team will develop methods for the synthesis of new O antigens of defined length, and the Polish team, as part of the NCN project, will describe how selected oligosaccharides in the form of glycoconjugates are processed and presented by antigen-presenting cells of the immune system. Further exploration of these processes will contribute to the design of effective glycoconjugate vaccines.

We offer work in a dynamic, interdisciplinary and friendly team conducting research in the field of immunochemistry of bacterial sugar antigens. LINK TO THE WEBSITE: https://hirszfeld.pl/struktura/laboratoria/laboratorium-immunochemii-drobnoustrojow-i-szczepionek/
Principal investigator: Prof. Jolanta Łukasiewicz, Laboratory of Microbial Immunochemistry and Vaccines, jolanta.lukasiewicz@hirszfeld.pl (ORCID: 0000-0001-8081-7261)

Tasks
(1) preparation of glycoconjugates for the purpose of obtaining monoclonal antibodies directed against selected P. aeruginosa antigens (bacterial cultures, antigen preparations, synthesis and purification of glycoconjugates, cooperation in the isolation of antibodies – immunoenzymatic and preparative methods, in vitro studies).
(2) verification of the structure of sugar antigens and their glycoconjugates using NMR spectroscopy and mass spectrometry.
(3) mapping of epitopes recognised by the obtained antibodies and sera using immunoenzymatic and instrumental methods, such as surface plasmon resonance (SPR, Biacore T200) and STD (saturation transfer difference)-NMR spectroscopy.
(4) participation in the preparation of reports and publications.

Typ konkursu NCN: Projekt międzynarodowy – NZ
Termin składania ofert: 6 kwietnia 2026, 15:00
Forma składania ofert: email
Warunki zatrudnienia:

Planned date of employment: 1 May 2026 or 1 June 2026.
Type of contract: employment contract, full-time position.
Employment period and remuneration: 24 months, remuneration PLN 11,666 gross/month.

Dodatkowe informacje:

https://hirszfeld.pl/instytut/oferty-pracy/

Data dodania ogłoszenia: 2026-03-16 09:41:53