Oferty pracy w projektach finansowanych przez NCN

Nazwa jednostki: Institute of Physical Chemistry PAS – Warsaw, Inne oferty z tego miasta »
Nazwa stanowiska: Post-doctoral position
Wymagania:

Post-doc position available in the Institute of Physical Chemistry PAS within National Science Center We seek a highly motivated and enthusiastic Postdoctoral Researcher at the Institute of Physical Chemistry, Polish Academy of Sciences. The position is part of the project entitled “Spatial determinants of immunotherapy resistance in cancer”, funded by the NCN (National Science Centre) in cooperation with the SNSF (Swiss National Science Foundation). Our laboratory at IPC PAS/ICTER provides an international and interdisciplinary research environment with close links to genomics, single-cell sequencing, molecular biology, biotechnology, and bioinformatics. The project involves multimodal (transcriptomic and epigenomic) and spatial profiling of tumor infiltrating immune cells using in-house high-throughput single-cell sequencing methods.
Details about the project:
Significant work over the last two decades has increased our understanding of the intricate, and sometimes opposing roles, that the immune system plays in cancer. While robust immune responses are required for sustained protective anti-tumor responses, tumor infiltrating CD8+ T cells which have the potential to control tumor growth, often acquire a dysfunctional state due to chronic antigen exposure in a nutrient depleted, and suppressive tumor microenvironment (TME). T cell dysfunction is characterized by a gradual loss of effector function coupled with increased expression of immune checkpoint receptors, including CTLA4, PD-1, Lag3 and Tim-3. As a consequence, immunecheckpoint therapy (ICI), using blocking antibodies against these receptors, has emerged as an important treatment modality for cancer. ICI has demonstrated unprecedented responses in patients with several types of metastatic tumors that were otherwise refractory to available treatment options. However recent studies show that across all indications only ~13% of patients respond to immunotherapy.

To date, the majority of efforts to understand how cancer immunotherapy restores anti-tumor T cell responses have concentrated on assessing the reactivation of dysfunctional T cells. It was largely thought that the efficacy of checkpoint blockade is mediated by the direct ability of blocking antibodies to bind to co-inhibitory molecules and reverse the state of T cell dysfunction. However, this concept has been challenged with seminal work demonstrating that existing intra-tumoral CD8+ T cells have limited capacity for rejuvenation with a relatively inflexible chromatin landscape, suggesting that the protective effect of ICI is unlikely to be due to reprogramming of dysfunctional T cells. Without a basic understanding of how ICI precisely works we cannot begin to understand why then, in the majority of patients, ICI fails. As such there is great interest in understanding ways to target other immune cells.

To address these questions, we have outlined a series of experiments to analyze the cellular and transcriptional changes associated with tumor infiltrating immune cells. This proposal is highly interdisciplinary implementing single-cell 'omics' strategies and systems immunology approaches to further unravel the players and rules governing immune responses during malignancy. In addition,we plan to develop a suite of computational tools that will allow us to better understand the organization of tumor microenvironment in terms of the cellular composition, spatial arrangement of cells and their communication.
Leader: dr Marcin Tabaka

Specific Requirements:
● Ph.D. degree in Biotechnology, Biology, Genomics, Medicine or related quantitative discipline obtained not earlier than 7 years before the engagement in the project (this period might be longer due to family reasons according to NCN rules);
· Solid knowledge and familiarity with techniques in Genomics;
● Familiarity with Next Generation Sequencing;
● Familiarity with single-cell methods in Genomics;
● Excellent communication and organizational skills;
● Ability to work independently and interact effectively in an interdisciplinary team;
● Proficiency in English, both spoken and written.

Candidate needs to meet formal requirements:

Ph.D. degree in Biotechnology, Biology, Genomics, Medicine or related quantitative discipline.
PhD obtained in the year of employment in the project or within 7 years before 1 January of the year of employment in the project.

Opis zadań:

● Designing, executing, analyzing, and interpreting experiments including high throughput single-cell multimodal profiling;
● Assessing quality controls of Next Generation Sequencing data generated in the project;
● Optimization of protocols for multimodal analyses (RNA-seq, ATAC-seq) of single cells;
● Prepare and write scientific papers for leading journals.

Typ konkursu NCN: Projekt międzynarodowy – NZ
Termin składania ofert: 15 lipca 2026, 12:00
Forma składania ofert: email
Warunki zatrudnienia:

Type of contract: temporary
• Status: full-time employment
• Hours Per Week: 40
Salary/month: Around 9600 PLN gross
Position starts on: 16.08.2026
Planned period of contract: 6 months with possible extension, not exceeding 2028-03-31.

Dodatkowe informacje:

We offer a post-doctoral position (full-time employment) in the Institute of Physical Chemistry PAS with a gross salary of Around 9600 PLN gross
per month financed from the NCN Weave-Unisono.
100% of the work time of Postdoc will be devoted to the realization of the proposed project. The offer is for 6 months with possible extension, not exceeding 2028-03-31. Career development prospects at IPC PAS:
The successful candidate will be eligible for all programs at the IPC PAS, including the IPC PAS Young Scientists competition and the IPC PAS Young Scientists Mobility competition.

Institute provides an opportunity to participate in ERASMUS+ programme.

Recruitment procedure:
· The application deadline is on the
15.07.2026 , 12:00 noon
Applications should be sent to rekrutacja@ichf.edu.pl. IMPORTANT! email subject: “Recruitment no 40/2026 ” (emails without this number will not be considered).
• Top candidates can be invited for an online or in-person interview (20-22.07.2026). We reserve the right to contact and reply to only selected candidates.
• The position will be offered to the person with the highest evaluation by the Recruitment Committee.
• The results of the recruitment are planned to be announced on the 31.07.2026.
• Employment will take place in accordance with the provisions of the competition documentation of the National Science Center (NSC) for the Weave-Unisono and Employment policy of the Institute of Physical Chemistry PAS https://ichf.edu.pl/files/csr/ipc-procedures.pdf .

• The incomplete applications may not be considered

• The results of the competition are made public.

• Candidates who have been issued a negative opinion by the Competition Committee or candidates not selected for employment have the right to appeal against the results of the evaluation. The appeal shall be lodged with the Director of the Institute within 7 days from the date of receipt of the appropriate information. The decision of the Director of the Institute shall be final.
Appeals should be sent to the following email address: dzgran@ichf.edu.pl.

•If the top candidate does not sign the contract due to the resignation, we reserve the right to choose the next candidate from the ranking list.

Key assessment criteria
The Commission will take into account the following criteria and evaluate applications on a point scale:
· Competence for specific tasks in a research project;
· Previous scientific achievements (publication record);
· Candidate’s own initiative in research projects.

Required documents:
-scientific curriculum vitae, including a list of scientific achievements (scholarships, publications, patents, conference presentations, etc.);
· motivation letter;
· a scan of the PhD diploma or other document confirming PhD degree

Deadline for the settlement of the competition:

Planned date: 31.07.2026.
By submitting the application you consent to the processing of your personal data in the recruitment process.
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Data dodania ogłoszenia: 2026-06-23 22:39:24