Oferty pracy w projektach finansowanych przez NCN

Nazwa jednostki: Institute of Physical Chemistry PAS – Warsaw, Inne oferty z tego miasta »
Nazwa stanowiska: Post-doctoral position
Wymagania:

Post-doc position available in the Institute of Physical Chemistry PAS within the National Science Center OPUS 30, Project no. 2025/59/B/NZ1/02711, entitled “Functional and Structural Characterization of Predicted Human Oxygenases with an Unusual Fe(II)-Binding Site”.

(leader Dr. Lennart Brewitz )
Team No. 16, Medical Chemistry, Protein Biochemistry and Biocatalysis

Profil naukowy kandydata - R2 - Recognised Researcher

Specific Requirements:
• A PhD degree in chemistry, biochemistry, or related scientific disciplines is required, obtained in the year of employment in the project or within 12 years before 1 January of the year of employment in the project. For researchers with multiple PhDs, the date of the first PhD award is deemed the reference date. Extensions might apply according to the rules of the National Science Centre, Poland;
• Additionally, the candidate for the postdoctoral position must meet the following condition: their PhD degree has been conferred by an institution other than the one employing them at this position. Otherwise, they must have completed a continuous and evidenced research fellowship of at least 9 months during their studies at the doctoral school, doctoral studies or after being conferred their PhD degree at another institution than the participating entity for the project and outside the country in which their PhD degree was conferred.
• Publication record and experience in research.
• Ability to work independently as well as in a group.
• Experience with at least one of the list: (preferably two or more):
1. Recombinant protein production
2. Protein purification
3. Enzyme activity assays and kinetics
4. Structural/crystallographic characterisation of proteins
5. Medicinal chemistry
• Ability to communicate fluently in English (written and spoken).
• Strong motivation to work and solving scientific problems, creativity, and analytical thinking

Candidates need to meet the following formal requirements:

The successful candidate for the postdoctoral position shall, for the full term of their employment within the project, be obligated to maintain compliance with the following conditions:
• their PhD degree has been conferred by an institution other than the one employing them at this position. Otherwise, they must have completed a continuous and evidenced research fellowship of at least 9 months during their studies at the doctoral school, doctoral studies or after being conferred their PhD degree at another institution than the participating entity for the project and outside the country in which their PhD degree was conferred;
• when the remuneration is paid, they will be receiving no remuneration paid from the funds granted to research projects under NCN calls under the heading of direct costs;
• when the remuneration is paid, they will be receiving no remuneration from another employer pursuant to an employment contract, including an employer with registered office outside of Poland; and
• when the remuneration is paid, they will be receiving no pension benefits or equivalent benefits in Poland or abroad.

A post-doc type post is a full-time post, scheduled by the project’s principal investigator for a person who has been conferred a PhD degree in the year of employment in the project or within 12 years before 1 January of the year of employment in the project. For researchers with multiple PhDs, the date of the first PhD award is deemed the reference date. This period may be extended by a time of long-term (in excess of 90 days) documented sick leaves or rehabilitation leaves granted on account of being unfit to work. In addition, the period may be extended by the number of months of a child care leave granted pursuant to the Labour Code and in the case of women, by 18 months for every child born or adopted, whichever manner of accounting for career breaks is preferable.

Opis zadań:

Project description:
Dioxygenases use molecular oxygen to modify their substrates, which can include proteins, nucleic acids, fatty acids, and small molecules. Because of their versatility, dioxygenases are involved in many essential cellular processes, such as breaking down fatty acids, signalling, and regulating gene expression. Dioxygenases are also important drug targets, and many widely used medicines work by blocking their activity.
Understanding how dioxygenases function, what substrates they act on, how they perform their reactions at the molecular level, and what their three-dimensional structures look like is crucial for developing medicines.
The objectives of this project are to characterise the function, substrates, and structure of two unusual human dioxygenases related to cancer. This knowledge, together with artificial intelligence-based methods, will be used to guide the development of molecules that selectively block the activity of these two dioxygenases to enable future cellular studies on their potential as cancer targets.
This project will employ a combination of state-of-the-art laboratory techniques to produce these two human dioxygenases in bacterial cells, to identify the natural molecules they modify (using e.g. NMR, MS, plate reader-based activity assays), and to determine their three-dimensional structures (using e.g. protein crystallography); part of the work will be carried out together with international collaborators. Collectively, the results of these investigations will inform on how these two dioxygenases work at the molecular level and will help to define their roles in both healthy and cancer cells.

Scientific discipline: Chemistry (Biochemistry, Reaction mechanisms and dynamics, Structural chemistry)

Responsibilities:
• Independently design, plan and conduct experiments related to the biochemical and structural characterisation of human dioxygenases
• Design, express and purify protein constructs
• Develop and perform enzyme activity assays
• Structurally characterise proteins
• Analyse data
• Effectively work together with students and international collaborators
• Oversee the work of students
• Disseminate research results at project meetings, in peer-reviewed journals and at international conferences

Typ konkursu NCN: OPUS – NZ
Termin składania ofert: 25 sierpnia 2026, 12:00
Forma składania ofert: email
Warunki zatrudnienia:

• Type of contract: temporary
• Status: full-time employment
• Hours Per Week: 40
Salary/month: Around 11700 PLN gross
Position starts on: 01.10.2026 (can be negotiated and adjusted)
An agreement will be signed with successful applicants on condition that the Institute of Physical Chemistry signs the grant agreement with NCN.
Planned period of contract: 12 months with the possibility of extension.

Dodatkowe informacje:

We offer:
We offer a post-doctoral position (full-time employment) in the Institute of Physical Chemistry PAS with a gross salary of around 11700 PLN per month financed from the NCN OPUS 30, Project no. 2025/59/B/NZ1/02711, entitled “Functional and Structural Characterization of Predicted Human Oxygenases with an Unusual Fe(II)-Binding Site”.
100% of the work time of Postdoc will be devoted to the realization of the proposed project. The offer is for 12 months with the possibility of extension.

Career development prospects at IPC PAS:
• The candidate will have the opportunity to work in a highly ambitious young research group at the interface of biochemistry, structural biology, and medicinal chemistry and perform work with high translational potential
• The candidate will have the opportunity to build an expertise in a plethora of state-of-the-art biochemical and biophysical techniques
• The candidate will have an opportunity to work in the laboratory of an international collaborator for some time
• The candidate will have an opportunity to present their work at international conferences
• The successful candidate will be eligible for all programs at the IPC PAS, including the IPC PAS Young Scientists competition and the IPC PAS Young Scientists Mobility competition. The IPC PAS provides the opportunity to participate in ERASMUS+ programme.

Recruitment procedure:
• The application deadline is on the 25.08.2026, 12:00 CEST (UTC +2:00)
• Applications should be sent to rekrutacja@ichf.edu.pl. IMPORTANT! email subject: “Recruitment no 46/2026” (emails without this number will not be considered)
• Top candidates can be invited for an online or in-person interview between 02.09.2026 and 03.09.2026
We reserve the right to contact and reply to only selected candidates.
• The position will be offered to the person with the highest evaluation by the Recruitment Committee.
• The results of the recruitment are planned to be announced on the 14.09.2026
• An agreement will be signed with successful applicants on condition that the Institute of Physical Chemistry signs the grant agreement with NCN.
• Employment will take place in accordance with the provisions of the competition documentation of the National Science Center (NSC) for the OPUS 30 call (https://www.ncn.gov.pl/en/ogloszenia/konkursy/opus30 ) and Employment policy of the Institute of Physical Chemistry PAS https://ichf.edu.pl/files/csr/ipc-procedures.pdf.
• Incomplete applications may not be considered
• The results of the competition will be made public
• Candidates who have been issued a negative opinion by the Competition Committee or candidates not selected for employment have the right to appeal against the results of the evaluation. The appeal shall be lodged with the Director of the Institute within 7 days from the date of receipt of the appropriate information. The decision of the Director of the Institute shall be final.
Appeals should be sent to the following email address: dzgran@ichf.edu.pl.
• If the top ranked candidate does not sign the contract due to the resignation, we reserve the right to choose the next candidate from the ranking list.

Key assessment criteria:
The Recruitment Commission will take into account the following criteria:
• Competence to perform specific tasks in the research project
• Previous scientific achievements, awards and distinctions resulting from prior conducted research

Required documents:
• A cover letter;
• An academic curriculum vitae;
• A list of scientific achievements (publications, patents, conference presentations and research projects);
• PhD certificate or other document confirming a PhD degree.

Dodatkowe informacje:
• Application Deadline: 25.08.2026, 12:00 CEST (UTC +2:00)
• Planned interviews: between 02.09.2026 and 03.09.2026
• The results of the recruitment are planned to be announced on: 14.09.2026
• For more details about the position please visit: https://ichf.edu.pl/en/groups/medical-chemistry-protein-biochemistry-and-biocatalysis

Contact person:
lennart.brewitz@ichf.edu.pl, Phone +48 22 343 2424

By submitting the application, you consent to the processing of your personal data in the recruitment process.

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https://ichf.edu.pl/theme/ichf/pliki/RODO_klauzula_informacyjna.pdf

Data dodania ogłoszenia: 2026-08-04 10:06:15