16th JPIAMR transnational call for research projects - AMR diagnostics and surveillance 2023 (DISTOMOS)

General Information

• Project title: Antimicrobial Resistance Prediction Using Laboratory Evolution
• Type: Project looking for partner
• Organisation: MHH and Helmholtz Centre for Infection Research
• Country: Germany (DE)
• Career stage: Early Career Researcher (up to 8 years** since PhD).

Research area

• Scientific area(s) of the call:
  1. Topic 1: to develop novel, or improve existing, diagnostics, including point of care diagnostics, that can rule out antimicrobial use or help identify the most effective antimicrobial treatment
• One Health Setting:

  Human Health

• Keywords:

  Experiment Evolution; Antibiotics; High-Throughput; Rapid Sequencing

• Brief description of your expertise / expertise you are looking for:

  We have expertise in high-throughput laboratory evolution and access to a large number of gram-negative bacterial clinical isolates from multiple hospitals that have been profiled, including their whole-genome sequence data. We plan to evolve these isolates to a wide range of conventional antibiotics to assess their adaptation potentials and evolutionary trajectories. We are interested in using rapid sequencing technologies and microscopy to quickly determine the most effective treatment regime.

• Brief description of your project / the project you would like to join:

  We are a group from Hannover Medical School/Helmholtz Centre for Infection Research in Germany, looking for: 1. Expertise in rapid sequencing methods that can aid rapid identification of antimicrobial resistance genes. 2. Expertise in AMR with gram-negative pathogens, mechanisms of action and bioinformatics support. 3. Expertise in high-throughput microscopy with gram-negatives. Or 4. University hospitals or academic teaching hospitals who can provide profiled E.coli or Psuedomonas clinical isolates

Adam Mulkern

• Organisation: MHH and Helmholtz Centre for Infection Research
• Position: Postdoctoral Fellow
• E-mail: adam.mulkern@helmholtz-hzi.de