16th JPIAMR transnational call for research projects - AMR diagnostics and surveillance 2023 (DISTOMOS)

General Information

• Project title: Host Immeune Response Implementation Registry
• Type: Project looking for partner
• Organisation: MeMed, Ltd.
• Country: Israel (IL)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: to develop novel, or improve existing, diagnostics, including point of care diagnostics, that can rule out antimicrobial use or help identify the most effective antimicrobial treatment
• One Health Setting:

  Human Health

• Keywords:

  POC; host immune response; Emergency Depratment (ED); Diagnostics ; Acute Respiratory Infections (ARI)

• Brief description of your expertise / expertise you are looking for:

  We are looking for partners from EU (JPIAMR funding only) countries to conduct our study in the acute care (Emergecy Department, Acute Assessment Unit, etc\') setting for either adults or pediatric (≥3 months old) patients

• Brief description of your project / the project you would like to join:

  Inappropriate prescribing of antibiotics exposes patients to unnecessary risks of adverse events and contributes to the global antibiotic resistance (AMR) crisis. The clinical uncertainty regarding the aetiology of infection, mainly the difficulty to distinguish between bacterial and viral infection, may lead to misuse of antibiotics. A novel host immune response test named MeMed BV (MeMed diagnostics, Israel) measuring 3 hot proteins (TRAIL, IP-10 and CRP) has shown ample evidence to aid in the distinction between bacterial and viral acute infections with the potential to reduce antibiotics over prescription. This has been shown in various settings including in the Emergency Department (ED), where the acuity and need for a rapid and highly performing diagnostic tests is needed. To implement a new test to daily routine, we wish provide clinicians with real world evidence (RWE) of impact on decision making and antibiotics prescribing patterns in the ED. In this JPIAMR DISTOMOS call we are looking to generate a transnational registry in order to understand the aforementioned impact. We will focus on acute respiratory infections (ARI) and the study will include the following main steps: •Pre-implementation: During this part, we will establish a list of data points to collect in order to understand antibiotics prescription rates and listing of the diagnostic process (e.g., diagnostics tests and operational time to reach decision). If current data allow, these could be collected retrospectively, otherwise we should allocate a period of data collection. •Implementation of the Memed BV: This will include full implementation and support (installation, service and education) to the clinical and laboratory teams. The Memed BV will be in use for a period of 6-12 months during which the data will be collected as mentioned above. •Post-implementation: Data analysis and publication of results. For more information, please contact Tomer Lamhoot at tomer.lamhoot@me-med.com or visit MeMed.com.

Tomer Lamhoot

• Organisation: MeMed, Ltd.
• Position:
• E-mail: tomer.lamhoot@me-med.com
• Phone: +44(0)7719384053
• Web: www.me-med.com/