17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Type: Partner looking for project
• Organisation: University of Padova
• Country: Italy (IT)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Design novel or improved interventions to prevent, mitigate and /or treat fungal infections, which are resistant to treatments and/or are at risk of developing resistance
• Subtopics:

• One Health Setting:

  Human Health

  Animal Health (incl. wildlife, livestock, acquatic organisms, and companion animals)
  Environment (incl. natural and built)

• Keywords:

  secreted toxins; elastase and metalloproteinases; transcription factors; theranostic nanobodies; target based drug discovery

• Brief description of your expertise / expertise you are looking for:

  Our research Group is mainly devoted to the characterization and engineering of biomolecules mainly driven by the support of Integrated Structural Techniques. Recombinant production of biomolecules in diverse systems is routinely applied in combination to biophysical methods to develop theranostic tools. A particular focus is devoted to nanobodies development and engineering, as well as targeting of protein-protein interactions and dynamics. Our lab is highly committed to providing a hub of biotechnologies based on the fundamentals of biochemistry, synthetic and structural biology. We are looking for research groups with expertise in microbiology and medicinal chemistry in order to build a team with complementary expertise and give our contribution to projects focused on the discovery and development of novel treatments to contrast and mitigate AMR.

• Brief description of your project / the project you would like to join:

  The type of projects we think we can contribute more are target based drug development projects, where we can contribute to characterize the target at the molecular level, as well as validate hits and lead compounds developed to bind and inhibit defined biomolecules, both by Structural and biophysical techniques. The novel hits discovered, either small molecules, or peptides or nanobodies/antibodies fragments, might be developed to become tools for both diagnostic and therapeutic applications.

Laura Cendron

• Organisation: University of Padova
• Position: Associate professor
• E-mail: laura.cendron@unipd.it
• Phone: +393207788380
• Web: www.researchgate.net/lab/Laura-Cendron-Lab