17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Type: Partner looking for project
• Organisation: Moldova State University
• Country: Moldova (MD)
• Career stage: Early Career Researcher (up to 8 years** since PhD).

Research area

• Scientific area(s) of the call:
  1. Topic 2: Improve and/or, compare and/or evaluate strategies, technologies, treatments, methods, protocols or data collection based on existing interventions, aiming to prevent or reduce the emergence or spread of antibacterial or antifungal resistance or to treat/cure infections caused by resistant bacteria/fungi and recommend new policies.
• Subtopics:
  1. Improve and/or compare and/ or evaluate the effectiveness of existing interventions (e.g. cost effectiveness clinical utility, socio-economic adaptability, reducing AMR emergence, spread, transmission, treatment etc.)

• One Health Setting:
  Environment (incl. natural and built)

• Keywords:

  wastewater; antibiotics; antibiotic resistance genes: bacterial degrading strain

• Brief description of your expertise / expertise you are looking for:

  As maintained by WHO and UNICEF, 780 million people do not have access to safe drinking water, of which 185 million use surface water to meet their daily needs. The risk associated with pollution with compounds derived from the pharmaceutical industry is highly topical.Among pharmaceutical compounds, antibiotics are receiving increased attention because they are responsible for the development of antibiotic-resistant bacteria and genes. Their presence in water bodies affects the aquatic ecosystem, and also poses a threat to human health. On the report of WHO (WHO, 2015), ≈10% of the drugs used by patients in the Republic of Moldova are antibiotics. A 2014 study showed that Moldavian people most often used the antibiotics ampicillin, amoxicillin, cephalothin, cefamandole etc. According to point prevalence survey of healthcare-associated infections and antimicrobial use in hospitals of the Republic of Moldova, conducted in 2018 under the auspices of the Ministry of Health, Labour and Social Protection, 43% of patients receive antibiotic treatment. Contamination of natural water by the pharmaceutical wastewater plays an essential role in the anthropogenesis impacts. Under action of different external factors, there comes to pass degradation of toxicants and formation of new substances including the more toxic ones. Removal of pharmaceutical compounds from the aqueous environment is one of the most significant priorities in the field of wastewater treatment. Having a complex composition, these pollutants are difficult to remove by conventional or biological methods, and the application of photochemical methods is an effective alternative. From this point of view, various advanced oxidation processes (AOPs) have shown the potential to remove antibiotic from an aqueous solution. Due to high non-degradability, non-toxicity, universal viability and acceptability AOPs has become a promising option for efficiently removing persistent pharmaceutical compounds. In this context, the main purpose of our team is to study the degradation/mineralization of drugs from aqueous solution by applying homogeneous and heterogeneous oxidation.

• Brief description of your project / the project you would like to join:

  We are interested in participating as a partner in consortium working on project under Topic 2.

Larisa Mocanu

• Organisation: Moldova State University
• Position: Research scientist
• E-mail: lmdordea@gmail.com
• Phone: +37369916796
• Web: orcid.org/0000-0003-3306-5292