17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Project title: Chemist/Medicinal Chemist for Lead Structure Optimisation
• Type: Project looking for partner
• Organisation: Griffith University
• Country: Australia (AU)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Design novel or improved interventions to prevent, mitigate and /or treat fungal infections, which are resistant to treatments and/or are at risk of developing resistance
• Subtopics:

• One Health Setting:

  Human Health

  Animal Health (incl. wildlife, livestock, acquatic organisms, and companion animals)

• Keywords:

  Chemistry Medicinal Chemistry Heterocyclic Chemistry

• Brief description of your expertise / expertise you are looking for:

  We are an interdisciplinary team composed of structural biologists/chemists and microbiologists, specialising in the cutting-edge fields of structure-guided drug design, Nuclear Magnetic Resonance (NMR) spectroscopy, and fungal microbiology. Our collaborative efforts are focused on the discovery and development of novel antifungal treatments. For our project we are seeking the specialised skills of a chemist or medicinal chemist. The ideal partner should have a robust background in heterocyclic chemistry, with a proven track record of optimising lead structures for enhanced efficacy, solubility, and bioavailability: # Strong expertise in heterocyclic chemistry, particularly in the synthesis and optimisation of small molecule inhibitors. # Experience in medicinal chemistry, with an understanding of drug design principles, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties, and optimisation strategies. # A collaborative spirit, eager to work within an interdisciplinary team

• Brief description of your project / the project you would like to join:

  Our research has led to the identification of novel compounds that have high anti-fungal potency. Our findings open the door to creating innovative antifungal treatments to combat the growing threat of Aspergillosis and its resistance to existing drugs. We are seeking a chemist/medicinal chemist partner with expertise in heterocyclic chemistry to join us in this exciting venture. Together, we aim to optimise these promising lead compounds and advance the development of much-needed antifungal therapies.

A/Prof Thomas Haselhorst

• Organisation: Griffith University
• Position: Research Leader
• E-mail: t.haselhorst@griffith.edu.au
• Phone: +61755527012
• Web: www.griffith.edu.au