17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Type: Partner looking for project
• Organisation: The Hebrew University
• Country: Israel (IL)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 2: Improve and/or, compare and/or evaluate strategies, technologies, treatments, methods, protocols or data collection based on existing interventions, aiming to prevent or reduce the emergence or spread of antibacterial or antifungal resistance or to treat/cure infections caused by resistant bacteria/fungi and recommend new policies.
• Subtopics:
  1. Improve and/or compare and/ or evaluate the effectiveness of existing interventions (e.g. cost effectiveness clinical utility, socio-economic adaptability, reducing AMR emergence, spread, transmission, treatment etc.)

• One Health Setting:

  Human Health

  Animal Health (incl. wildlife, livestock, acquatic organisms, and companion animals)

• Keywords:

  Novel therapeutic reagent; empty viral capsid; multi-targeting; sepsis

• Brief description of your expertise / expertise you are looking for:

  We are developing a novel therapeutic reagent. In our studies on sepsis-induced ARDS (Ben-Nun-Shaul 2020, Oncotarget 11:574-588) we discovered that our reagent functions by activating multiple defense pathways within the host, including iNOS and defensin, thus directly killing infecting pathogens. Unlike bacteria, which have a short life span and and a high mutability, the host pathways are fairly stable. We therefore anticipate that the reagent will not be affected by antimicrobial resistance nor lead to the emergence of resistant pathogen strains. In addition, we anticipate that the reagent will not be limited to a single strain or class of pathogens.

• Brief description of your project / the project you would like to join:

  We would like to join a project which compares strategies for fighting AMR, preferably using the same pre-clinical model(s) and by exchanging material.

Ariella Oppenheim

• Organisation: The Hebrew University
• Position: P.I.
• E-mail: ariellao@mail.huji.ac.il
• Phone: +972-52-3296346