17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Type: Partner looking for project
• Organisation: MIGAL Galilee research institute
• Country: Israel (IL)
• Career stage: Early Career Researcher (up to 8 years** since PhD).

Research area

• Scientific area(s) of the call:
  1. Topic 2: Improve and/or, compare and/or evaluate strategies, technologies, treatments, methods, protocols or data collection based on existing interventions, aiming to prevent or reduce the emergence or spread of antibacterial or antifungal resistance or to treat/cure infections caused by resistant bacteria/fungi and recommend new policies.
• Subtopics:
  1. Improve and/or compare and/ or evaluate the effectiveness of existing interventions (e.g. cost effectiveness clinical utility, socio-economic adaptability, reducing AMR emergence, spread, transmission, treatment etc.)
  2. Identify the barriers to uptake, including factors leading to the success or failure of previously run pilot interventions, and when applicable design solutions to overcome them.

• One Health Setting:

  Human Health

• Keywords:

  Phage therapy; bacteria; stress response; antibiotic tolerance; persistence

• Brief description of your expertise / expertise you are looking for:

  My lab is expert in the molecular biology of phage-bacteria interaction. Our research is focused on understanding how bacterial adaptation to the environment affect the efficiency of phage infection. Specifically we focused on the stringent response in the model Gram positive bacterium Bacillus subtitles. Stringent response is active during \'abiotic\' stress, e.g., salt, ethanol, oxidative agents, nutrient limitation and more. Similar conditions are common during phage therapy application in the \'real world\' in the human body and on medical devices.

• Brief description of your project / the project you would like to join:

  We would like to join a project dealing with phage therapy. Phages, the natural enemies of bacteria are promising solution to the crisis of antibiotic resistance. However, their widespread application is still facing challenges. We believe that better understanding how bacterial adaptation to the environment affect phage infection is essential to any project aiming to improve phage therapy application.

Elhanan Tzipilevich

• Organisation: MIGAL Galilee research institute
• Position: P.I
• E-mail: Elhanant@migal.org.il
• Web: scholar.google.com/citations?user=Pt4IdpkAAAAJ&hl=en