17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Type: Partner looking for project
• Organisation: University of Portsmouth
• Country: United Kingdom (UK)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Design novel or improved interventions to prevent, mitigate and /or treat fungal infections, which are resistant to treatments and/or are at risk of developing resistance
• Subtopics:

• One Health Setting:

  Human Health

  Animal Health (incl. wildlife, livestock, acquatic organisms, and companion animals)

• Keywords:

  two-component systems; in vivo assay; phenotypic screening; molecular dynamics; ligand docking

• Brief description of your expertise / expertise you are looking for:

  Our research group has 20+ years experience with two-component signalling systems. We have established and conducted various screening methodologies against two-component signalling systems. We have recently expanded into various computational methods including atomistic structural prediction, membrane-embedding and atomistic molecular dynamics. Our strength resides in the fact that we can rapidly perform successive rounds of computational and wet-lab experimentation that inform each other.

• Brief description of your project / the project you would like to join:

  We are currently working on several two-component signalling pathways and would be interested into moving from antibacterial to antifungal targets. These two-component systems exist in a very limited number in mammalian cells and would be excellent antifungal targets.

Dr Roger DRAHEIM

• Organisation: University of Portsmouth
• Position: Associate Professor in Synthetic Microbiology, Associate Head of School (Research and Innovation)
• E-mail: roger.draheim@port.ac.uk
• Phone: +44 (0) 23 9284 2133
• Web: www.port.ac.uk/about-us/structure-and-governance/our-people/our-staff/roger-draheim