17th JPIAMR transnational call for research projects - AMR Interventions 2024 (IMPACT)

General Information

• Project title: Therapeutic Agents for Antibacterial/Antifungal Photodynamic Applications
• Type: Project looking for partner
• Organisation: A1 Chem Innovation GmbH
• Country: Germany (DE)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Design novel or improved interventions to prevent, mitigate and /or treat fungal infections, which are resistant to treatments and/or are at risk of developing resistance
• Subtopics:

• One Health Setting:

  Human Health

  Animal Health (incl. wildlife, livestock, acquatic organisms, and companion animals)
  Environment (incl. natural and built)

• Keywords:

  Photodynamic therapuetic intervention to tackle multidrug-resistant microbes

• Brief description of your expertise / expertise you are looking for:

  We are a start-up (spin-off from Univ.) with extensive knowledge in discovery chemistry, expertise in designing and synthesizing organic chromophores,and complex compounds. We have knowledge in many areas of imaging, and looking for experts in the field of antibacterial therapies including imaging and translational knowledge for a consortia project.

• Brief description of your project / the project you would like to join:

  Photodynamic therapy (PDT), a treatment strategy using photosensitizers (PS) and light to produce short-lived ROS to induce cell death, has long been investigated for cancer therapy and to tackle multidrug resistance bacteria. Antibacterial PDT has been proven as an effective method to eliminate Gram-positive and Gram-negative strains, as well as highly effective against different fungi. However, the administered PS do not selectively accumulate in bacteria but also in mammalian cells, and a selective irradiation of bacteria only is not possible, causing phototoxic side effects. Our solution is a redox-active PS dye that becomes inactive in mammalian cells but remains active against microbials. First studies of PSs, in vitro, confirm the safety to human cells, and suitability for antibacterial therapy. To expand and further develop this concept, we are looking for research partners with available animal models for bacterial infections and their imaging capabilities.

A1 Chem Innovation

• Organisation: A1 Chem Innovation GmbH
• Position: CEO
• E-mail: info@a1-chem.de
• Phone: 00492418096385
• Web: a1-chem.de