IMPRESS-U Call Partner Search Tool

General Information

• Project title: Combating Hypoxia to prevent Right Ventricular Failure in experimental pulmonary hypertension through - role of energetic, fibrosis and sex – a step toward personalized therapy (H-RVF)
• Type: Project looking for partner
• Organisation: Department of Clinical Physiology, Centre of Postgraduate Medical Education
• Country: Poland (PL)

Research area

• NSF calls:
  • EAGER
  • International Supplements
• Keywords:

  right ventricular fialure; pulmonary hypertension; heart failure; cardiovascular disease

• Brief description of your expertise / expertise you are looking for:

  My expertise: rat models of right ventricular failure caused by pulmonary hypertension (monocrotaline, pulmonary artery banding, left heart disease - post-myocardial infarction); human explanted hearts (end-stage heart failure and healthy hearts unused for transplantation) and isolated cells from these hearts. Expertise we are looking for: anything that will contribute to the project

• Brief description of your project / the project you would like to join:

  We and others have shown that right ventricular (RV) hypoxia is a universal finding in various forms of RV failure (RVF) and precedes the development of over failure. Therefore we hypothesize that prevention of RV hypoxia could prevent or at least delay the development of RVF. Thus our goal is to verify if hypoxia-combating strategies are able to prevent the development of RVF in two rat models of RVF: pulmonary artery banding (RV overload, mimicking PAH, PH-pulmonary disease and thromboembolic PH) and post-myocardial infarction (mimicking PH-LHD) and study its mechanisms. Specifically, the project will address the following research questions. Do hypoxia and impaired energetics drive the development of RVF? Does hypoxia impair red blood cell metabolism that contributes to RVF pathology? Can alleviation of hypoxia by ITPP improve RV function and survival? Is RV fibrosis the eventual mediator of hypoxia in RV pathology? Are there sex-related differences in response to RV overload and hypoxia? Are there sex-related differences in ITPP effectiveness? Can we get a glimpse of these pathologies in humans?

Michal Maczewski

• Organisation: Department of Clinical Physiology, Centre of Postgraduate Medical Education
• Position:
• E-mail: michal.maczewski@cmkp.edu.pl
• Phone: +48225693840
• Web: www.researchgate.net/profile/Michal-Maczewski