OHAMR Call for proposals 2026

General Information

• Type: Partner looking for project
• Organisation: Queen\'s University Belfast
• Country: United Kingdom (UK)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Identify and develop new combination treatments using existing or innovative antimicrobials or antimicrobial with adjunctive treatments to extend drug efficacy and combat resistance.
• One Health Setting:

  H - Human Health

  A - Animal Health
  P - Plants (Plant Health)

• Keywords:

  Antimicrobial peptides; Colistin; Gram-Negative Bacteria; Colistin-resistance; Carbapenem-resistance

• Brief description of your expertise / expertise you are looking for:

  Novel, patented, antimicrobial peptides active against multidrug resistant Gram-negative bacteria, including colistin- and carpabenem-resistant strains. In vivo efficacy demonstrated. Less nephrotoxic than colistin.

• Brief description of your project / the project you would like to join:

  Some ideas: 1) Our peptide + colistin Hypothesis: lower colistin dose + peptide maintains/boosts efficacy while reducing nephrotoxicity. Test synergy and resistance suppression vs WHO priority Gram-negatives. PK/PD work to design combination dosing regimens that are clinically realistic. 2) Our peptide + carbapenem / other generic agents Aim: re-sensitise carbapenem-resistant strains, or allow lower doses of toxic agents. Show that the combination extends useful life of cheap drugs, which the call explicitly wants.

Stephen Cochrane

• Organisation: Queen\'s University Belfast
• Position: Professor of Medicinal Chemistry and Chemical Biology
• E-mail: s.cochrane@qub.ac.uk
• Web: www.cochranelab.com