OHAMR Call for proposals 2026

General Information

• Type: Partner looking for project
• Organisation: Helmholtz
• Country: Germany (DE)
• Career stage: Other.

Research area

• Scientific area(s) of the call:
  1. Topic 1: Identify and develop new combination treatments using existing or innovative antimicrobials or antimicrobial with adjunctive treatments to extend drug efficacy and combat resistance.
• One Health Setting:

  H - Human Health

• Keywords:

  medchem; ADMET; synthesis; Galleria mellonella

• Brief description of your expertise / expertise you are looking for:

  We employ a range of hit-identification strategies, including structure- and fragment-based drug design, virtual screening, high-throughput screening and a variety of biophysical methods. In addition, we pioneer innovative protein-templated techniques like dynamic combinatorial chemistry and kinetic target-guided synthesis, to address key bottlenecks in drug discovery. We use classical and innovative medicinal-chemistry approaches to design, synthesize and profile the most promising inhibitors, enabling efficient subsequent multiparameter optimization. Various in vitro and cell-based assays, the generation of in silico data, elucidation of the mode of action and the co-crystallization of selected compounds with their targets support the straightforward evaluation of novel anti-infectives and their further optimization. In the OH-AMR context we offer our expertise mentioned above, and in more detail, in medicinal chemistry, in vitro ADMET profiling, and in vivo Galleria mellonella models.

• Brief description of your project / the project you would like to join:

  We would be delighted to contribute our expertise as outlined above and participate in an anti-infective project that requires expertise in areas such as medicinal chemistry, in vitro ADMET profiling, and/or in vivo Galleria mellonella models.

Anna Hirsch

• Organisation: Helmholtz
• Position: Professor
• E-mail: anna.hirsch@helmholtz-hips.de
• Phone: +49 681 98806 2100
• Web: www.helmholtz-hips.de/de/