This is a match-making section for OHAMR Call for proposals 2026.
H - Human Health
A - Animal HealthReverse-ecology metabolic trade-offs population genomics
We bring expertise in microbial population genomics and reverse ecology. We are looking for experts in microbial metabolism and/or a particular pathogen group from the bacterial priority pathogens list.
This project applies a reverse ecology and population-genomic framework to identify metabolic vulnerabilities in ecologically differentiated subpopulations of key pathogenic bacteria. We will predict metabolic targets within these subpopulations that generate fitness trade-offs under antimicrobial stress, then systematically screen the substrates or products associated with those targets to assess their interactions with antibiotic susceptibility. By coupling population-specific metabolic profiling with antimicrobial interaction assays, this work aims to identify metabolic trade-offs that can be therapeutically leveraged to improve treatment outcomes.
Submitted on 2025-12-03 07:25:17
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