JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: Institute of Bioorganic Chemistry, Polish Academy of Sciences
• Country: Poland (PL)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
  2. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
  3. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  structural biology; macromolecular crystallography; antibiotic resistance; antibacterial drug design; Pseudomonas aeruginosa

• Brief description of your expertise / expertise you are looking for:

  Our group develops novel inhibition strategies against enzymes of pathogenic origin. We apply a broad range of methods from the intersection of microbiology, biochemistry, and biophysics, including macromolecular crystallography, Cryo-EM single particle analysis, ITC, and high-throughput enzyme kinetics. Our current studies concern: 1. Structural enzymology of bacterial enzymes involved in methylation reactions. 2. Development of species-specific inhibitors targeting the enzymes from pathogenic microorganisms. 3. High-throughput macromolecular crystallography. 4. Crystallographic studies of biologically active small molecules. 5. X-ray diffraction studies of non-crystalline (bio)materials.

• Brief description of your project / the project you would like to join:

  We would like to join the rational antibacterial drug design project that requires the implementation of structural biology and biophysics approaches.

Krzysztof Brzezinski

• Organisation: Institute of Bioorganic Chemistry, Polish Academy of Sciences
• Position: Professor of the Institute
• E-mail: kbrzezinski@ibch.poznan.pl
• Web: portal.ichb.pl/department-of-structural-biology-of-prokaryotic-organisms/