JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: University of Milan
• Country: Italy (IT)

Research area

• Scientific area(s) of the call:
  1. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
  2. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  light-activated antimicrobials ; photoswitchable drugs ; phototherapy ; photopharmacology ; antibiotic resistance

• Brief description of your expertise / expertise you are looking for:

  I am an organic and medicinal chemist with over 15 years of research experience working on small-molecule drug discovery projects, with a special expertise in the design and synthesis of photoswitchable drugs. Together with my collaborators, we could take care of the design and chemical synthesis of innovative small molecule antimicrobials. https://pubmed.ncbi.nlm.nih.gov/?term=carlo+matera+photoswitchable

• Brief description of your project / the project you would like to join:

  Antimicrobials are life-saving drugs, but their excessive application and accumulation in the environment causes antimicrobial resistance, one of the most important health problems of today’s society. In this regard light can be an unparalleled tool. Its properties, such as orthogonality to most of biological processes, resilience to sample contamination, and the ease with which it can be delivered with high spatiotemporal resolution, make it ideal for controlling drugs\' activity. Photoswitchable drugs could offer a solution to the occurrence of antimicrobial resistance, since their pharmacological activity could be reversibly controlled with light in time and space, thus reducing the environmental side effects of these molecules. My research group (2-3 medicinal chemists) would be happy to join a consortium interested in studying photoswitchable antimicrobials as innovative therapeutic agents that could limit the occurrence of resistance.

Carlo Matera

• Organisation: University of Milan
• Position: Assistant Professor
• E-mail: carlo.matera@unimi.it
• Web: www.researchgate.net/profile/Carlo-Matera