JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: University of Bristol
• Country: United Kingdom (UK)

Research area

• Scientific area(s) of the call:
  1. Drug/plant protection agent repurposing
  2. Optimisation of drug/plant protection agent combinations, alone or with adjunct therapies (including therapeutic vaccines)
  3. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
• One Health Setting:

  Human Health

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  Quorum sening; Antifungal resistance; Biofilm; Polymicrobial infections; Microbial interactions

• Brief description of your expertise / expertise you are looking for:

  My major research interest has been to elucidate physical and chemical interactions of microbes in competitive polymicrobial environments (fungal-bacterial biofilm communities in particular) to understand in depth the physiology of microbial communal lifestyle, as well as to define novel molecular pathways that can be targeted for translational research in future in orvercoming antimicrobial resistance. In particular, the work I have undertaken thus far aims to characterize the response of the human fungal pathogen Candida to various bacterial quorum sensing signals (QSMs) using an inter–kingdom, fungal-bacterial interaction model system. Therefore, I have expertise and experience in the techniques in microbiology (biofilm models, antimicrobial resting, microbiological assays), advanced microscopy (Confocal laser scanning microscopy, scan electron microscopy, transmission electron microscopy), molecular biology (qPCR, RNA-Seq, proteomics, etc.), biochemistry (e.g. HPLC, liquid chromatography and mass spectrometry) and pharmaceutics (drug formulations and drug delivery).

• Brief description of your project / the project you would like to join:

  I would like to join a project which focuses on improving the efficacy of existing antifungal/antibacterial agents, developing novel agents and/or co-delivering them to eliminate human/animal pathogens, particularly those that would be effective against polymicrobial biofilms.

Nihal Bandara

• Organisation: University of Bristol
• Position: Senior Lecturer
• E-mail: nihal.bandara@bristol.ac.uk
• Web: www.bristol.ac.uk/people/person/Nihal-Bandara-803915f0-3dc3-46b1-a801-12d71259ed4c/