This is a match-making section for JPIAMR 14th call - Disrupting drug Resistance Using Innovative Design (DRUID).
Human Health Animal Health (including wild-life, livestock, fishes, and companion animals)
in silico, in vitro, in vivo
Biofilm bacterial infections antibiotic tolerance antibiotic resistance anti-adhesion
In parallel to the worldwide emergence of genetically transmissible antibiotic resistance in pathogenic bacteria, the development of biofilms on medical surfaces or mucosa also constitutes an important cause of therapeutic failures due to their capacity to survive to very high concentrations of antibiotics. Our laboratory uses different in vitro and in vivo biofilm models combined with genetics, genomics and molecular biology approaches to study biofilm-specific physiological properties such as antibiotic tolerance and emergence of antibiotic resistance in biofilms formed by pathogenic bacteria. We also develop new strategies to control or limit the extent of pathogenic or detrimental biofilms in clinical situations, in which they represent a major health threat. See also: https://research.pasteur.fr/en/team/genetics-of-biofilms/
We are keen on joining a dynamic JPIAMR consortium to contribute to an axis on in vitro and in vivo approaches to control bacterial biofilms or validation of molecules preventing the emergence of antibiotic resistance in planktonic and biofilm conditions
Submitted on 2022-01-14 16:09:17
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