JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: Sapienza University of Rome
• Country: Italy (IT)

Research area

• Scientific area(s) of the call:
  1. Optimisation of drug/plant protection agent combinations, alone or with adjunct therapies (including therapeutic vaccines)
  2. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health Animal Health (including wild-life, livestock, fishes, and companion animals) Plants (including trees and crops)

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  Antibiotic resistance; Bdellovibrio; microbiota; resistoma

• Brief description of your expertise / expertise you are looking for:

  The group of research expertise (two researchers) embrace studies on antibiotic resistance and alternative or adjuvant strategies such as: bacterial predators; natural/synthetic substances and bacterial products; procedure concerning the transplantation of faecal microbiota for the treatment of antibiotic resistant Clostridium difficile colitis and other diseases related to gut dysbiosis.

• Brief description of your project / the project you would like to join:

  Our research group would like to "join projects" concerning the study on antibiotics alternative strategies, for example the study of synthetic or natural compounds with antibiotic-adjuvant properties, or study on the use of bacterial predators such as Bdellovibrio bacteriovorus to overcome problems of antibiotic resistance. As "partner looking for project", we will have a multitasking approach that involves the use of innovative molecular and cellular approaches. We will be able to evaluate: a) The cytotoxicity towards different cell lines and their impact through the evaluation of the inflammatory induction levels by the evaluation of non-inflammatory and inflammatory cytokines; b) the MIC and MBC value against different bacterial species; c) the synergistic interaction activity between different antimicrobial substances; d) the bacterial biofilms features and antimicrobial resistances.

Fabrizio Pantanella

• Organisation: Sapienza University of Rome
• Position: Researcher
• E-mail: FABRIZIO.PANTANELLA@UNIROMA1.IT