JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: IIM-CSIC
• Country: Spain (ES)

Research area

• Scientific area(s) of the call:
  1. Optimisation of drug/plant protection agent combinations, alone or with adjunct therapies (including therapeutic vaccines)
  2. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
• One Health Setting:

  Animal Health (including wild-life, livestock, fishes, and companion animals)

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  Mathematical models; Optimisation; Pharmacokinetics; Pharmacodynamics; Preditive Microbiology

• Brief description of your expertise / expertise you are looking for:

  We work on mathematical modelling and optimisation of the dynamics in antimicrobial-bacteria interaction. We are a theoretical group that has been collaborating with researchers interesting in the dynamics of bacteria in the food and animal settings through what is called predictive microbiology: modelling the dynamics (growth and death) of bacteria under different stressors such as antimicrobials.

• Brief description of your project / the project you would like to join:

  We are interested in joining a project with the experimental potential to measure bacterial dynamics under different antimicrobials to, using mathematics, optimise the drug profile. Once a mathematical is obtained, we can infer the best therapies to decrease resistance. Some examples: Is it better a continuous addition of the drug, or adding it at constant concentrations at different times, which times? When the combination of drugs is possible, is there any synergy, which profile of each drug is better to decrease resistance?

Míriam R. García

• Organisation: IIM-CSIC
• Position:
• E-mail: miriamr@iim.csic.es
• Web: resistance.iim.csic.es/