JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: University of Toronto
• Country: Canada (CA)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
• One Health Setting:

  Human Health Animal Health (including wild-life, livestock, fishes, and companion animals) Plants (including trees and crops)

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  structural biology; drug development; structure-activity-relationships; efficacy; specificity

• Brief description of your expertise / expertise you are looking for:

  Our lab specializes in structure-function studies of antibacterial and antifungal drug targets, as well as resistance determinants i.e. antibiotic-modifying enzymes. We participate in the Center for Structural Genomics of Infectious Diseases (CSGID), funded by the National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) USA. We have determined more than 200 crystal structures and are one of the most pre-eminent centers for structural biology of AMR. We have more than 40+ years of expertise in: -protein purification -protein crystallization -cryo-EM -protein 3D structure determination and analysis -drug + drug target complex structure determination and analysis -structure-activity-relationships -in vitro activity assay development -3D structure modeling -docking, virtual screening -antimicrobial susceptibility testing (AST)

• Brief description of your project / the project you would like to join:

  We have deep expertise in particular drug classes including but not limited to: aminoglycosides, macrolides, streptogramins, glycopeptides, lincosamides and sulfonamides. We are looking to join a consortium to improve the efficacy and/or specificity of antimicrobials and can contribute the above expertise to your project.

Peter Stogios

• Organisation: University of Toronto
• Position: Senior Research Associate
• E-mail: p.stogios@utoronto.ca
• Web: www.biozone.utoronto.ca