JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: University of British Columbia
• Country: Canada (CA)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
  2. Drug/plant protection agent repurposing
  3. Optimisation of drug/plant protection agent combinations, alone or with adjunct therapies (including therapeutic vaccines)
  4. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
• One Health Setting:

  Human Health

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  Tuberculosis AMR Host pathogen interaction Mode of actions HTS High Content assays

• Brief description of your expertise / expertise you are looking for:

  Our lab expertise is on monitoring Intracellular growth of Mycobacteria inside infected macrophages, cell lines and primary cells with and without drugs. Identification of drug targets and mode of action of novel compounds either within the bug or within the host-pathogen interaction. We have a state of the art BCL-3 facility capable of working with AMR and clinical isolates of Mycobacterium tuberculosis and NTMs.

• Brief description of your project / the project you would like to join:

  Development of novel compounds targeting XDR and MDR TB. Repurposing drugs for TB and NTM. Synergy studies in an in vitro and ex vivo assays. Hit to Lead projects.

Yossef Av-Gay

• Organisation: University of British Columbia
• Position: Professor
• E-mail: yossi@mail.ubc.ca
• Phone: 6046031806
• Web: av-gaylab.med.ubc.ca