JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: INRAE
• Country: France (FR)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
  2. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
  3. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  In silico modeling; Medicinal chemistry; encapsulation; microbiology; animal assays

• Brief description of your expertise / expertise you are looking for:

  We propose a complementary expertise to assess and improve chemistry, drug efficacy and delivery: -In silico target modeling, structured-guided mutagenesis and potentiation of drug/target binding -Medicinal chemistry and drug encapsulation -Functional assays and microbiology of bacterial pathogens (ie K. pneumoniae, E. coli, P. aeruginosa, Bacillus…) -Animal models (insects and mice) for in vivo activity and early stage PK/PD

• Brief description of your project / the project you would like to join:

  We are keen on joining a JPIAMR consortium to contribute to in silico, in vitro and in vivo approaches for the identification/validation of molecules preventing the emergence of antibiotic resistance.

Nalini Rama Rao

• Organisation: INRAE
• Position: Director of research
• E-mail: nalini.ramarao@inrae.fr
• Web: www.micalis.fr/Poles-et-Equipes/Pole-Adaptation-Bacterienne-et-Pathogenese/Pathogenes-Immunite-et-Microbiote-Nalini-Ramarao ; joliot.cea.fr/drf/joliot/Pages/Entites_de_recherche/medicaments_technologies_sante/SCBM/lcb.aspx