JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: Keele University
• Country: United Kingdom (UK)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
  2. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health Animal Health (including wild-life, livestock, fishes, and companion animals) Plants (including trees and crops)

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo preclinical and clinical studies in human and in all veterinary settings

• Keywords:

  Chemical modification synthesis natural products peptides biofilms

• Brief description of your expertise / expertise you are looking for:

  We are interested in searching new therapies for infectious diseases. We are performing mass spectrometry-based metabolomics analysis, bioassay-guided isolation and structural elucidation of antibacterial and antimalarial natural products such as alkaloids, cyclic peptides and terpenoids from medicinal plants, fungi and marine resources. In addition, we also make the analogues of hit compounds via biotransformation and chemical modification to study their structure-activity relationships, to improve their physicochemical properties and to investigate their mechanisms of action.

• Brief description of your project / the project you would like to join:

  We would like to join any projects aiming to 1) discover novel antimicrobial agents and improve the hit compounds by chemical modification/biotransformation, and 2) design and implement innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials.

Dr. Wen-Wu Li

• Organisation: Keele University
• Position: Senior Lecturer
• E-mail: w.li@keele.ac.uk
• Phone: 0044 17862 674382
• Web: www.keele.ac.uk/pharmacy-bioengineering/ourpeople/wen-wuli/