JPIAMR 14th Call Partner Search Tool

General Information

• Type: Partner looking for project
• Organisation: University of Gothenburg
• Country: Sweden (SE)

Research area

• Scientific area(s) of the call:
  1. Improvement of drug/plant protection agent efficacy and/or specificity through chemical modifications (including hit to lead optimisation)
  2. Design and implementation of new strategies (including optimisation of drug doses) for improved application, efficacy and delivery of single or combinations of antimicrobials
  3. Design and implementation of innovative tools, including novel chemistry and/or new materials for improved application, efficacy and delivery of antimicrobials
• One Health Setting:

  Human Health Animal Health (including wild-life, livestock, fishes, and companion animals) Plants (including trees and crops)

• Type of studies/experimental approaches:

  in silico, in vitro, in vivo

• Keywords:

  Bioactive peptides bioconjugations peptide mimetics novel compounds genome mining

• Brief description of your expertise / expertise you are looking for:

  The collaborative consortium is located in Sweden and in Chile and combines expertise in peptide chemistry, chemical biology, analytical chemistry, mass spectrometry, nuclear magnetic resonance, microbiology, antibiotic resistance, novel compounds, molecular biology, genome mining, genomics, proteomics, with principal investigators: Dr. Alesia Tietze (University of Gothenburg, Department of Chemistry and Molecular Biology, Division of Organic and Medicinal Chemistry, Wallenberg Centre for Molecular and Translational Medicine (WCMTM, https://www.gu.se/en/molecular-translational-medicine, www.tietze-lab.com ) is an expert in chemical biology with a pronounced focus in peptide chemistry. Her group is a part of a WCMTM, therefore the unique infrastructure is provided and translation into application upon identification and characterization of bioactive compounds. She has an extensive experience in peptide analytics, manipulation, and isolation. Her research focuses on development of synthetic strategies for bioactive peptides/ derived from marine organisms and conjugation techniques, design of biomimetic structures and elucidation their mode of action. Dr. Beatriz Cámara (Universidad Técnica Federico Santa María in Valparaiso, Chile) - expertise in isolation and cultivation of actinomycetes, antimicrobial assays, metabolomics, comparative genomics, optimization of fermentative conditions for actinobacterial strains, and the utilization of genetic engineering strategies to produce bioactive compounds. Dr. Roger Karlsson (Clinical microbiology, Sahlgrenska University Hospital, UGOT) has extensive experience in applications of mass spectrometry (MS) and proteomics for microorganisms and bioanalytical chemistry.

• Brief description of your project / the project you would like to join:

  Our expertise is in rational design of peptides and peptide mimetics towards improved bioactive properties. Strong expertise in bioconjugation techniques and exploration of SAR properties of novel bioactive peptides. We identify and experimentally characterize unique anti-microbial compounds from biosynthetic genes encoding non-ribosomal peptide synthetases in unique marine habitats from Chilean Comau Fjord. Current studies led to identification of a set of antimicrobial peptide-mimetics based on the core structure identified from genome analysis of actinobacteria. We are a part of the Centre for Antibiotic Resistance (CARe) (https://www.gu.se/en/care/genome-based-natural-product-discovery-characterization-of-bioactive-compounds-in-marine-actinobacteria) with a beneficial access to GU Culture Collection (www.ccug.se)

Alesia Tietze

• Organisation: University of Gothenburg
• Position: Associate Professor
• E-mail: alesia.a.tietze@gu.se
• Web: www.tietze-lab.com